Table 1. Markers used in CEC assays.
Marker | Description | Subtype association | Expression level | Coexpression | References |
---|---|---|---|---|---|
CD31 | PECAM-1 | Pan-endothelial | ++a | P, Pan-leukocyte | (Beerepoot et al, 2004) |
CD34 | Stem cell marker | Pan-endothelial | ++a | S | (Furstenberger et al, 2006) |
CD36 | Collagen receptor I | Micro vascular | +a | P, E, M, D | (Moroni et al, 2005) |
CD54 | ICAM-1 | Inflammation | +a | L, M | (Dixon et al, 2004) |
CD62-E | E-selectin | Inflammation | ++ | — | (Dixon et al, 2004) |
CD62-P | P-selectin | Inflammation | + | P | (Corcoran et al, 2006) |
CD105 | Endoglin | Angiogenesis, malignant | ++a | S, Mb | (Rowand et al, 2007) |
CD106 | VCAM-1 | Inflammation, malignant | +a | — | (Dixon et al, 2004) |
CD137 | ILA/4 | Malignant | + | Lb, D | (Seaman et al, 2007) |
CD144 | VE-cadherin | Pan-endothelial | +a | — | (Smirnov et al, 2006) |
CD146 | MelCAM | Pan-endothelial | ++a | Lb | (Dignat-George et al, 2007) |
CD202b | Tie-2 | Angiogenesis | (+)a | — | (Smirnov et al, 2006) |
CD276 | B7-H3 | Malignant | + | D, Mb | (Seaman et al, 2007) |
CD309 | VEGFR-2 | Angiogenesis | (+)a | S | (Beerepoot et al, 2004) |
VWF | Pan-endothelial | ++a | P | (Woywodt et al, 2006) | |
UEA-1 | Pan-endothelial | ++ | — | (Woywodt et al, 2006) | |
DiL-AcLDL | Pan-endothelial | ++ | — | (Voyta et al, 1984) |
PECAM-1=platelet/endothelial cell adhesion molecule 1, ICAM-1=intracellular adhesion molecule 1, VCAM-1=vascular cellular adhesion molecule 1, ILA/4=inducible by lymphocyte activation /4, MelCAM=melanoma-associated cellular adhesion molecule, Tie-2=angiopoietin-1, 2, 4 receptor, B7-H3=B7 homologue 3, VEGFR-2=vascular endothelial growth factor receptor 2. S=hematopoietic stem cells, L=lymphocytes, P=platelets, M=monocytes, E=erythrocytes, D=dendritic cells.
Expression levels: ++=strong, +=moderate, (+)=weak.
Indicates data based on flow cytometric results from the authors.
Indicates presence on activated cells.