Table 3.
Transcriptional differences: tumor vs normal tissue derived EC
| Unigene Cluster | Symbol | Gene Name | |
| Structural | A | ||
| Hs.370287 | ADAM23 | A disintegrin and metalloproteinase domain 23 | |
| Hs.118127 | ACTC | Actin, alpha, cardiac muscle | |
| Hs.533336 | BAMBI | BMP and activin membrane-bound inhibitor homolog | |
| Hs.489142 | COL1A2 | Collagen, type I, alpha 2 | |
| Hs.443625 | COL3A1 | Collagen, type III, alpha 1 | |
| Hs.210283 | COL5A1 | Collagen, type V, alpha 1 | |
| Hs.211933 | COL13A1 | Collagen, type XIII, alpha 1 | |
| Hs.409034 | COL15A1 | Collagen, type XV, alpha 1 | |
| Hs.80552 | DPT | Dermatopontin | |
| Hs.412597 | DSG2 | Desmoglein 2 | |
| Hs.159291 | DRP2 | Dystrophin related protein 2 | |
| Hs.371903 | GYPE | Glycophorin E | |
| Hs.190495 | GPNMB | Glycoprotein (transmembrane) nmb | |
| Hs.328232 | GPC1 | Glypican 1 | |
| Hs.435557 | KIF5C | Kinesin family member 5C | |
| Hs.436367 | LAMA3 | Laminin, alpha 3 | |
| Hs.519972 | HLA-F | Major histocompatibility complex, class I, F | |
| Hs.490874 | MTX1 | Metaxin 1 | |
| Hs.464469 | MYOM1 | Myomesin 1 (skelemin) | |
| Hs.504687 | MYL9 | Myosin, light polypeptide 9, regulatory | |
| Hs.464829 | CDH2 | N-cadherin | |
| Hs.116471 | CDH11 | OB-cadherin | |
| Hs.487925 | PDE4DIP | Phosphodiesterase 4D interacting protein (myomegalin) | |
| Hs.157818 | KCNAB1 | Potassium voltage-gated channel, shaker-related subfamily, beta member 1 | |
| Hs.407643 | PCDH9 | Protocadherin 9 | |
| Hs.106511 | PCDH17 | Hypothetical protein LOC144997 | |
| Hs.7972 | RIPX | Rap2 interacting protein x | |
| Hs.73800 | SELP | Selectin P | |
| Hs.468675 | T1A-2 | T1A-2 (lung type-I cell membrane-associated glycoprotein) | |
| Hs.143250 | TNC | Tenascin C | |
| Hs.371147 | THBS2 | Thrombospondin 2 | |
| Hs.443681 | CSPG2 | Versican | |
| Hs.529901 | XIST | X (inactive)-specific transcript | |
| Enzymatic | B | ||
| Hs.459538 | ALDH1A3 | Aldehyde dehydrogenase 1 family, member A3 | |
| Hs.421202 | ABCA2 | ATP-binding cassette, sub-family A (ABC1), member 2 | |
| Hs.489033 | ABCB1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | |
| Hs.646 | CPA3 | Carboxypeptidase A3 | |
| Hs.75360 | CPE | Carboxypeptidase E | |
| Hs.252549 | CTSZ | Cathepsin Z | |
| Hs.154654 | CYP1B1 | Cytochrome P450, family 1, subfamily B, polypeptide 1 | |
| Hs.516493 | FAP | Fibroblast activation protein, alpha | |
| Hs.30332 | GFPT2 | Glutamine-fructose-6-phosphate transaminase 2 | |
| Hs.301961 | GSTM1 | Glutathione S-transferase M1 | |
| Hs.470126 | KYNU | Kynureninase (L-kynurenine hydrolase) | |
| Hs.65436 | LOXL1 | Lysyl oxidase-like 1 | |
| Hs.307734 | MME | Membrane metallo-endopeptidase | |
| Hs.478289 | NLGN1 | Neuroligin 1 | |
| Hs.30954 | PMVK | Phosphomevalonate kinase | |
| Hs.77274 | PLAU | Plasminogen activator, urokinase | |
| Hs.446429 | PTGDS | Prostaglandin D2 synthase 21 kDa | |
| Hs.501280 | PRSS11 | Protease, serine, 11 (IGF binding) | |
| Hs.303090 | PPP1R3C | Protein phosphatase 1, regulatory (inhibitor) subunit 3C | |
| Hs.128013 | PRSS3 | Protease, serine, 3 | |
| Hs.270279 | TYRP1 | Tyrosinase-related protein 1 | |
| Hs.13225 | B4GALT4 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 | |
| Hs.69009 | B3GNT3 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 | |
| Signaling | C | ||
| Hs.143102 | AB012943 | Amine oxidase, copper containing 2 | |
| Hs.167046 | ADORA2B | Adenosine A2b receptor | |
| Hs.483909 | ADMR | Adrenomedullin receptor | |
| Hs.132902 | CAP2 | CAP, adenylate cyclase-associated protein, 2 (yeast) | |
| Hs.502328 | CD44 | CD44 antigen | |
| Hs.78065 | C7 | Complement component 7 | |
| Hs.473133 | DOK5 | Docking protein 5 | |
| Hs.523173 | ENTPD1 | Ectonucleoside triphosphate diphosphohydrolase 1 | |
| Hs.511899 | EDN1 | Endothelin 1 | |
| Hs.1407 | EDN2 | Endothelin 2 | |
| Hs.183713 | EDNRA | Endothelin receptor type A | |
| Hs.481371 | FAT | FAT tumor suppressor homolog 1 (Drosophila) | |
| Hs.352 | FOLR3 | Folate receptor 3 (gamma) | |
| Hs.432395 | GPR39 | G protein-coupled receptor 39 | |
| Hs.79022 | GEM | GTP binding protein overexpressed in skeletal muscle | |
| Hs.198612 | GPR51 | G protein-coupled receptor 51 | |
| Hs.156855 | GABRG3 | Gamma-aminobutyric acid (GABA) A receptor, gamma 3 | |
| Hs.167017 | GABBR1 | Gamma-aminobutyric acid (GABA) B receptor, 1 | |
| Hs.98262 | GRIK2 | Glutamate receptor, ionotropic, kainate 2 | |
| Hs.124161 | HCN2 | Hyperpolarization activated cyclic nucleotide-gated potassium channel 2 | |
| Hs.370984 | IGSF4C | Immunoglobulin superfamily, member 4C | |
| Hs.438102 | IGFBP2 | Insulin-like growth factor binding protein 2 | |
| Hs.369982 | IGFBP5 | Insulin-like growth factor binding protein 5 | |
| Hs.81134 | IL1RN | Interleukin 1 receptor antagonist | |
| Hs.126256 | IL1B | Interleukin 1, beta | |
| Hs.129751 | IL17R | Interleukin 17 receptor | |
| Hs.514535 | LGALS3BP | Lectin, galactoside-binding, soluble, 3 binding protein | |
| Hs.125474 | LPXN | Leupaxin | |
| Hs.36566 | LIMK1 | LIM domain kinase 1 | |
| Hs.304475 | LCP2 | Lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76 kDa) | |
| Hs.418367 | NMU | Neuromedin U | |
| Hs.514556 | NPTX1 | Neuronal pentraxin I | |
| Hs.8546 | NOTCH3 | Notch homolog 3 (Drosophila) | |
| Hs.434255 | PSD3 | Pleckstrin and Sec7 domain containing 3 | |
| Hs.506076 | PTPRR | Protein tyrosine phosphatase, receptor type, R | |
| Hs.436456 | ROR1 | Receptor tyrosine kinase-like orphan receptor 1 | |
| Hs.24950 | RGS5 | Regulator of G-protein signalling 5 | |
| Hs.194691 | RAI3 | Retinoic acid induced 3 | |
| Hs.95655 | SECTM1 | Secreted and transmembrane 1 | |
| Hs.516726 | SCG2 | Secretogranin II (chromogranin C) | |
| Hs.156540 | SGNE1 | Secretory granule, neuroendocrine protein 1 (7B2 protein) | |
| Hs.75149 | SH3GL2 | SH3-domain GRB2-like 2 | |
| Hs.444915 | SLC1A1 | Solute carrier family 1, member 1 | |
| Hs.448520 | SLC7A2 | Solute carrier family 7, member 2 | |
| Hs.351306 | SLC16A4 | Solute carrier family 16, member 4 | |
| Hs.192686 | SLC20A2 | Solute carrier family 20, member 2 | |
| Hs.12409 | SST | Somatostatin | |
| Hs.62886 | SPARCL1 | SPARC-like 1 (mast9, hevin) | |
| Hs.233160 | STC2 | Stanniocalcin 2 | |
| Hs.258326 | LOC51760 | Synaptotagmin 1 | |
| Hs.349470 | SNCG | Synuclein, gamma | |
| Hs.62192 | TF | Tissue factor | |
| Hs.534363 | UCN | Urocortin | |
| Hs.73793 | VEGF | Vascular endothelial growth factor | |
| Hs.306251 | ERBB3 | V-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | |
| Transcriptional factors and regulators | D | ||
| Hs.65734 | ARNTL | Aryl hydrocarbon receptor nuclear translocator-like | |
| Hs.397705 | CAMTA1 | Calmodulin binding transcription activator 1 | |
| Hs.157002 | DZIP1 | DAZ interacting protein 1 | |
| Hs.22634 | ETV1 | ets variant gene 1 | |
| Hs.155591 | FOXF1 | Forkhead box F1 | |
| Hs.519385 | FOXD1 | Forkhead related activator 4 (FREAC-4) | |
| Hs.121443 | HOP | Homeodomain-only protein | |
| Hs.180919 | ID2 | Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | |
| Hs.371013 | JMJD2B | Jumonji domain containing 2B | |
| Hs.434284 | LRRC17 | Leucine rich repeat containing 17 | |
| Hs.527007 | MEOX2 | Mesenchyme homeo box 2 (growth arrest-specific homeo box) | |
| Hs.89404 | MSX2 | Msh homeo box homolog 2 (Drosophila) | |
| Hs.1497 | RARG | Retinoic acid receptor, gamma | |
| Hs.149261 | RUNX1 | Runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) | |
| Hs.465087 | SMAD7 | SMAD, mothers against DPP homolog 7 (Drosophila) | |
| Hs.360174 | SNAI2 | Snail homolog 2 (Drosophila) | |
| Hs.89583 | TLX1 | T-cell leukemia, homeobox 1 | |
| Hs.149991 | THOC2 | THO complex 2 | |
| Hs.125962 | TFEC | Transcription factor EC | |
| Hs.1145 | WT1 | Wilms tumor 1 | |
| Hs.490510 | ZNF212 | Zinc finger protein 212 | |
| Hs.22653 | ZNF365 | Zinc finger protein 365 | |
| Hs.147765 | ZNF415 | Zinc finger protein 415 | |
| DNA replication, Cell Cycle and Apoptosis | E | ||
| Hs.75823 | AF1Q | ALL1-fused gene from chromosome 1q | |
| Hs.150749 | BCL2 | B-cell CLL/lymphoma 2 | |
| Hs.122908 | CDT1 | DNA replication factor | |
| Hs.9999 | EMP3 | Epithelial membrane protein 3 | |
| Hs.52903 | 8FSTL3 | Follistatin-like 3 (secreted glycoprotein) | |
| Hs.130853 | HIST1H2BD | Histone 1, H2bd | |
| Hs.534369 | HIST1H2BE | Histone 1, H2be | |
| Hs.152944 | LOH11CR2A | Loss of heterozygosity, 11, chromosomal region 2, gene A | |
| Hs.432132 | G0S2 | Putative lymphocyte G0/G1 switch gene | |
| Hs.514913 | SERPINB2 | Serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2 | |
| Others and unknown | F | ||
| Hs.441783 | C14orf78 | C14orf78 | |
| Hs.516956 | C20orf91 | chromosome 20 open reading frame 91 Hs.17936 | |
| DKFZP434H132 | DKFZP434H132 protein | ||
| Hs.132994 | DKFZP434C171 | DKFZP434C171 protein | |
| Hs.41707 | HSPB3 | Heat shock 27 kDa protein 3 | |
| Hs.432616 | IMP-3 | IGF-II mRNA-binding protein 3 | |
| Hs.534372 | INE1 | Inactivation escape 1 | |
| Hs.464563 | KIAA0802 | KIAA0802 | |
| Hs.65750 | KIAA1086 | KIAA1086 | |
| Hs.472010 | PRNP | Prion protein (p27-30) | |
| AC006276 | |||
| U62317 | |||
| W26626 | |||
| W28546 | |||
List of the 158 gene transcipts more expressed by HOC-EC than HA-EC.
Three HOC-EC and two HA-EC populations were investigated by Affymetrix GeneChip® Human Genome U95A Arrays and analyzed searchingfor intrinsic differences, as described in Methods.