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. 2004 Feb 3;90(3):705–711. doi: 10.1038/sj.bjc.6601490

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Copyright © 2004 Cancer Research UK

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Immunohistochemical analysis of gastric tumours after a single dose of ZD6126. Representative images of tumour sections stained with haematoxylin and eosin (column 1; × 40 magnification), stained for endothelial cell proliferation by immunofluorescence for CD31/BrdU (column 2; × 100) and stained for endothelial cell apoptosis by immunofluorescence against CD31/TUNEL (column 4, × 100). A single dose of ZD6126 caused a significant decrease in the number of dividing endothelial cells (as determined by colocalisation) and an increase in endothelial cells undergoing apoptosis, such that microvessel density was decreased by day 5.