Table 1. Treatment of gastric cancer with ZD6126.
ZD6126 (100 mg kg−1) |
|||
---|---|---|---|
Control | Weekly | Daily | |
Body mass (g)±s.e.m. | 30.9±0.8 | 31.3±1.0 | 29.2±0.7 |
Tumour volume (mm3)±s.e.m. | 440±154 | 241±39b | 79±25a |
Tumour mass (g)±s.e.m. | 0.5±0.1 | 0.4±0.1 | 0.2±0.1b |
Incidence of carcinomatosis | 10/12 (83.3%) | 6/12 (50%) | 1/11 (9.1%)c |
TMK-1 was injected into the gastric wall on day 0. Therapy with ZD6126, either once a week (weekly) or 5 × per week (daily), was initiated on day 14. Mice were killed on day 38.
P<0.002 by Student's t-test.
P<0.05 by Student's t-test.
P<0.01 by χ2 analysis.