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. 2004 Feb 17;90(4):917–925. doi: 10.1038/sj.bjc.6601581

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Copyright © 2004 Cancer Research UK

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C₆-SM uptake enhancement is optimal for amphiphilic compounds. During a 60 min period, confluent BAEC were allowed to take up one of a series of fluorescent compounds, either in the absence (control) or presence of 10 μM C₆-SM. After washing, drug accumulation was determined by fluorimetric analysis of the cell lysates. The C₆-SM effect on cellular accumulation of the compounds is expressed as percentage to the controls (mean±s.d., n=4). These data are plotted against the (log) lipophilicity of each compound, as determined by its partition ratio over a two-phase system consisting of 1-octanol and water (mean±s.d., n=4).