Table 2. Endothelial cell apoptosis and blood flow inhibition in tumours from C57Bl/6, TNF^–/− and TNFR^–/− mice following DMXAA treatment.

	Percentage TUNEL-stained areas			Hoechst-stained vessels mm−2
DMXAA	C57Bl/6	TNF−/−	TNFR−/−	C57Bl/6	TNF−/−	TNFR−/−
0	0.2±0.1	0.2±0.1	0.3±0.1	29.9±1.4	32.5±1.7	35.7±2.7
25 mg kg−1	2.5±1.0	1.4±0.5	0.3±0.1	5.6±1.0	13.6±1.4	31.3±1.3
50 mg kg−1	—	2.8±0.8	1.9±0.6	—	6.0±0.5	6.0±0.6

DMXAA=5,6-dimethylxanthenone-4-acetic acid.