Table 1. Characteristics of the evaluated patients.
Pt. no. | Sex | Age (years) | Prior tumour therapy (best response) | Karnofski (%) | Clinical status at start | Metastasis | Number of infusions | Response after first cycle | Survival (months; until January 2002) |
---|---|---|---|---|---|---|---|---|---|
1 | M | 68 | IFN+Vinbl (PD) | 90–100 | PD | Adrenal | 12 | PD | 6 |
2 | F | 45 | IFN+Vinbl (PD) | 70 | PD | Lung and liver | 4 | PD | 2 |
3 | F | 75 | None | 80 | PD | Lung | 12 | PD | 4 |
4 | M | 51 | None | 80 | PD | Lung, liver and LN | 11 | PD | 3 |
5 | F | 77 | None | 90 | PD | Lung | 5 | PD | 2 |
6a | M | 66 | IFN+Vinbl (SD) | 80 | PD | Lung and liver | 20 | SD | 18+ |
IFN+Vinbl (PD) | |||||||||
5FU+CF (PD) | |||||||||
7 | F | 58 | Radiation (PD) | 90–100 | PD | Lung | 12 | PD | 18+ |
8 | M | 77 | IFN+Vinbl | 80 | PD | Lung and bone | 4 | PD | Date unknown |
5FU+CF | |||||||||
9a | M | 68 | IFN+Vinbl (SD) | 90–100 | PD | Lung, pleura, adrenal | 20 | SD | 18+ |
5FU+CF (SD) | |||||||||
10 | M | 69 | IL-2/IFN/5FU (SD) | 90–100 | PD | Lung and liver | 12 | PD | 18+ |
IL-2/IFN/5FU red (PD) | |||||||||
11 | M | 66 | None | 90–100 | PD | Lung and LN | 12 | PD | 17 |
12 | F | 67 | None | 90–100 | UN | Liver, spleen and LN | 12 | PD | 18+ |
13 | F | 64 | IFN+Vinbl (PD) | 90–100 | PD | Lung and liver | 11 | PD | 4 |
14 | M | 72 | None | 90–100 | PD | Lung | 7 | PD | 1 |
15 | M | 51 | IFN+Vinbl (PD) | 90–100 | PD | Lung, LN, pancreas | 12 | PD | 17+ |
16 | M | 54 | IFN+Vinbl (PD) | 90–100 | PD | LN, contralateral kidney and psoas muscle | 12 | SD | 17+ |
IFN+cis-RA (PD) | |||||||||
5FU+CF (PD) | |||||||||
17 | M | 67 | IFN+Vinbl | 80 | PD | Lung | 5 | PD | 7 |
18 | M | 50 | IFN (PD) | 90–100 | PD | Lung | 12 | PD | 9 |
19 | M | 43 | None | 90–100 | PD | Lung and LN | 12 | PD | 8 |
20 | F | 60 | None | 80 | UN | LN | 12 | PD | 11 |
21a | M | 69 | None | 90–100 | UN | Lung and LN | 20 | SD | 16+ |
22a | M | 70 | None | 90–100 | UN | LN | 20 | SD | 13 |
23a | M | 61 | None | 80 | PD | Lung, LN and Liver | 20 | SD | 16+ |
24a | M | 56 | IL-2 (SD) | 90–100 | PD | LN | 20 | SD | 15+ |
DC vaccination (SD) | |||||||||
25a | F | 52 | IFN+cis-RA (CR) | 90–100 | PD | Other kidney | 20 | SD | 15+ |
26 | M | 69 | IL-2/IFN/5FU (PD) | 80 | PD | Lung and LN | 12 | PD | 15+ |
27a | M | 57 | IL-2/IFN/5FU (PR) | 90–100 | UN | Lung | 20 | SD | 15+ |
28a | F | 76 | None | 90–100 | PD | Lung and adrenal | 20 | SD | 14 |
29 | M | 66 | IL-2/IFN/5FU (SD) | 80 | PD | Lung and LN | 12 | PD | 15+ |
IL-2 inhalation (PD) | |||||||||
30 | F | 65 | IL-2/IFN/5FU (PD) | 90–100 | PD | Lung and LN | 12 | PD | 14+ |
Toremifene+Vinbl (PD) | |||||||||
31 | F | 70 | IFN+Vinbl (PR) | 90–100 | PD | Lung | 12 | PD | 14+ |
IFN+Vinbl (PD) | |||||||||
IFN+Vinbl (PD) | |||||||||
32 | M | 76 | None | 90–100 | PD | Lung | 12 | PD | 14+ |
33 | M | 71 | None | 80 | PD | LN and pleura | 12 | PD | 14+ |
34 | M | 57 | Vaccination (PD) | 90–100 | PD | Lung | 12 | PD | 7 |
35 | M | 67 | IFN+cis-RA (SD) | 90–100 | PD | Lung and LN | 10 | PD | 5 |
36a | F | 73 | None | 80 | PD | Lung | 20 | SD | 13+ |
Patients who received extended treatment.
Sex: M=male, F=female; response: PD=progressive disease, SD=stable disease, PR=partial response, CR=complete response, UN=unknown; metastasis: LN=lymphnode; prior treatment: IFN=interferon-alpha, Vinbl=vinblastine, 5FU=5-fluorouracil, CF=calcium folinate, IL-2=interleukin-2, cis-RA=cis-retinoic acid, DC=dendritic cell.