Table 3. ORs for prostate cancer and diabetes among men aged 65–79 years by risk factor strata.
|
History of diabetes |
|||
|---|---|---|---|
| NoCase/control | YesCase/control | aORa (95% CI) for diabetes and prostate cancer by strata | |
| Stage at prostate cancer diagnosis | |||
| Local | 254/289 | 48/100 | 0.54 (0.36, 0.80) |
| Advanced | 76/289 | 24/100 | 1.00 (0.58, 1.70) |
| Prostate cancer screening (PSA and DRE annually)a | |||
| Less than annual | 133/152 | 29/54 | 0.61 (0.36, 1.01) |
| Annualb | 186/131 | 54/42 | 0.68 (0.41, 1.12) |
| Age at diagnosis (years) | |||
| 65–69 | 152/120 | 35/50 | 0.59 (0.36, 0.99) |
| 70–74 | 104/84 | 25/30 | 0.65 (0.34, 1.24) |
| 75–79 | 74/85 | 12/20 | 0.72 (0.33, 1.60) |
| Race | |||
| Caucasian | 200/190 | 40/36 | 1.08 (0.66, 1.78) |
| African-American | 130/99 | 32/64 | 0.36 (0.21, 0.62) |
| Family history of prostate cancer | |||
| No | 230/247 | 48/80 | 0.64 (0.43, 0.98) |
| Yes | 98/40 | 22/20 | 0.47 (0.22, 1.00) |
| History of benign prostatic hyperplasia | |||
| No | 201/204 | 37/80 | 0.46 (0.29, 0.73) |
| Yes | 124/82 | 35/20 | 1.12 (0.60, 2.10) |
| BMI (kg m−2) | |||
| Normal weight (⩽24.9 BMI) | 96/98 | 9/15 | 0.58 (0.33, 1.01) |
| Overweight (25.0–29.9 BMI) | 169/134 | 29/41 | 0.62 (0.33, 1.15) |
| Obese (⩾30.0 MI) | 61/52 | 32/42 | 0.62 (0.33, 1.15) |
a
Adjusted for age (categorical variable), race (African-American compared with Whites), South Carolina region (three areas), and prostate cancer screening in the past 5 years before the referent date (yes annual screening vs no).
b
Annual defined as PSA or DRE at least once a year for the past 5 years.
OR=odds ratios; aOR=adjusted odds ratio; CI=confidence interval; BMI=body mass index; PSA=prostate-specific antigen; DRE=digital rectal exam.