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SFRP-4 interferes with Wnt-3a signalling in Lines 31E + 30F co-cultures. pBabeSFRP-4-infected, puromycin-selected, 31E cells in co-culture with 30F cells fail to show Wnt and Akt signalling activation by Wnt-3a. Treatment with Wnt-3a induced a hyperphosphorylation of Dvl-3, an increase in Akt phosphorylation (Ser473), and raised the levels of "active" β-catenin in the absence (pBabeV, vector), but not in the presence of the SFRP-4 cells.
