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. 2008 May 13;5:15. doi: 10.1186/1742-2094-5-15

Figure 3.

Figure 3

Minocycline facilitates recovery from LPS-induced sickness behavior. Mice were injected i.p. with vehicle or minocycline for three consecutive days. On the third day mice were challenged with saline or LPS i.p. A) Social exploratory behavior was measured before i.p. LPS injection and again 2, 4, 8, and 24 h later. Graph represents the mean ± SEM (n = 10). Means with * are significantly different (P < 0.05) from saline controls and means with ‡ are significantly different from Vehicle LPS. In the same experiment, B) body weight and C) food intake were measured before i.p. LPS injection and again 2, 4, 8, and 24 h later. Bars represent the mean ± SEM (n = 10). Means with different letters (a, b, c, or d) are significantly different (P < 0.05) from each other.