Table 3.
Area under ROC curve (AUC), sensitivity (Sn) and specificity (Sp) values for Predikin and five comparable methods
| Ser/Thr | CMGC | Tyr | |||||||
| Method | AUC | Sn % | Sp % | AUC | Sn % | Sp % | AUC | Sn % | Sp % |
| SDR1,2 | 0.86 (0.04) | 75.5 (9.2) | 86.6 (7.2) | 0.93 (0.02) | 89.4 (2.9) | 91.3 (2.1) | n/a | n/a | n/a |
| KSD2 | 0.86 (0.05) | 73.7 (10.1) | 90.0 (9.3) | 0.88 (0.02) | 83.8 (3.5) | 94.1 (1.1) | 0.76 (0.07) | 73.0 (13.3) | 79.7 (17.9) |
| PANTHER2 | 0.88 (0.04) | 74.6 (5.0) | 94.2 (1.8) | 0.91 (0.03) | 85.5 (6.4) | 93.4 (2.1) | 0.66 (0.09) | 61.0 (5.5) | 79.9 (13.8) |
| GPS | 0.83 | 76.0 | 87.2 | 0.94 | 97.8 | 89.8 | 0.72 | 56.0 | 88.2 |
| KinasePhos | 0.78 | 52.9 | 92.5 | 0.95 | 90.8 | 86.6 | 0.89 | 80.0 | 85.1 |
| NetPhosK | 0.90 | 86.3 | 78.8 | 0.57 | 16.8 | 95.4 | 0.68 | 60.0 | 71.4 |
| PPSP | 0.92 | 92.2 | 83.6 | 0.95 | 97.8 | 89.5 | 0.81 | 60.0 | 98.1 |
| Scansite | 0.95 | 86.3 | 93.3 | 0.94 | 94.6 | 87.8 | 0.70 | 64.0 | 93.2 |
1SDR method not applicable to Tyr kinases
2AUC, sensitivity and specificity values are the mean and standard deviation (in parentheses) of 10 cross-validation tests