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. Author manuscript; available in PMC: 2009 Jun 1.

Published in final edited form as: J Mol Graph Model. 2007 Nov 17;26(8):1189–1201. doi: 10.1016/j.jmgm.2007.11.001

Table 1.

S1P receptor agonist potencies

Structure	Binding affinity (IC₅₀, nM)^a
Structure	S1P₁	S1P₂	S1P₃	S1P₄	S1P₅
	0.67	0.35	0.26	34	0.55
	2.3	580	3.6	140	13
	0.28	>10000	6.3	15	0.77
	18	>10000	4900	5400	11
	37	>10000	>10000	>10000	4600
Structure	Activation (EC₅₀, nM)^b
Structure	S1P₁	S1P₂	S1P₃	S1P₄	S1P₅
	20	2.2	1.2	37	1.7
	37 (partial)	NA^c	NA^c	48	6.6 (partial)

^a

Data from Hale, et al. ³⁷

^b

Data from Clemens, et al.³⁸

^c

No activation