Figure 4. Antigen presentation by MEP-mel transfected DC is proteasome-dependent.
MEP-mel-transfected DC incubated with the proteasome blocker lactacystin inhibited stimulation of CD8+ T-cell lines specific for the four peptides contained in MEP-mel. Individual results from two independent experiments (exp1 and exp2) are presented. w/lacta – with lactacystin; w/o lacta – without lactacystin.