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. 2008 Jun 9;205(6):1277–1283. doi: 10.1084/jem.20080162

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© 2008 Plitas et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jgp.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 1. — TLR9^−/− mice have less inflammation and increased survival after CLP. (A) The survival rates of WT B6 and TLR9^−/− mice were monitored for 6 d after CLP (15 mice per group, with data pooled from three experiments, each of which had similar statistical significance). Dilutions of blood (B) or peritoneal lavage fluid (C) obtained from TLR9^−/− or WT mice 12 h after CLP were cultured on BHI agar plates, and the number of bacterial colonies was counted (five mice per group). The colony count indicated is of 1 ml of blood and 1 ml of peritoneal fluid. (D) Serum cytokine levels were determined 6 and 12 h after CLP by using a cytometric bead array (five mice per group). Data shown are means of values ± SEM obtained from individual mice and are representative of at least two independent experiments. *, P < 0.05.