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. 2008 Jun 9;205(6):1331–1342. doi: 10.1084/jem.20071555

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© 2008 Weller et al.

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Figure 4. — IgD⁺CD27⁺CD1c^high cells are already present in the SMZ of an 8-mo-old child. Serial splenic cryosections were double-labeled either with anti-IgD (green) and anti-CD27 (red) antibodies (A–D) or with anti-IgD (green) and anti-CD1c (red) antibodies (E–H), and then examined under a confocal microscope. CD27^low cells (B and D) were present in the MZ corresponding to the outer zone of the IgD-positive ring surrounding the GC (A and C). Boxes with dotted lines in A and B indicate the zone magnified in C and D. A higher level of CD1c expression was observed in the MZ (F), resulting in a yellow appearance in the merged images (G and H), caused by the coexpression of IgD and CD1c at similar intensities. H shows higher magnification of the zone delimited by the box with dotted lines in G. Co, corona. Bars, 50 μm.