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. 2008 Jun 9;205(6):1343–1355. doi: 10.1084/jem.20071572

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© 2008 Shimomura et al.

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Figure 6. — Intestinal CD21⁻CD23⁻ B cell development is independent of spleen and organization lymphoid tissues. Intestinal inflammation was induced in WT (Day 0, n = 8; Day 8, n = 8) and LTα KO (Day 0, n = 5; Day 8, n = 5) and splenectomized LTα (SP[-] LTα; Day 0, n = 5; Day 8, n = 5) mice. (A) Expressions of IgM versus CD21 or CD23 on large intestinal cells from LTα KO mice are shown. (B) Proportions (IgM/CD3ε) in large intestinal cells at day 8 are shown. (C) Absolute numbers of large intestinal IgM⁺ cells at day 0 (normal, open bar) and day 8 (recovery, shaded bar) are shown. (D and E) The inflamed intestine from LTα KO (D) and splenectomized LTα KO (E) mice were subjected to immunohistochemical analysis for the detection of IgM⁺ cells. (F) Expressions of IgM versus CD21 or CD23 on the gated B220⁺ cells from the normal colon (Day 0) of splenectomized LTα KO mice are shown. Bars, 100 μm.