Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2008 Jun 9;205(6):1343–1355. doi: 10.1084/jem.20071572

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2008 Shimomura et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jgp.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 7. — Intestinal CD21⁻CD23⁻ IgM⁺ B cells are not associated with B1 lineage cell. (A) RAG1 KO mice that had been reconstituted with peritoneal B1 cells from WT mice were treated with 4% DSS for 4 d and killed at day 8. The DSS-treated recipient mice show sufficient reconstitution of CD11b^low IgM⁺ B 1 cells in the peritoneal cavity (PC, left), whereas no IgM⁺ B cells are detectable in the inflamed mucosa (LP, right) of these mice. The data are representative of four individual recipient mice. (B–D) Intestinal inflammation was induced in WT (Day 0, n = 6; Day 8, n = 6), Rac2 KO (Day 0, n = 5; Day 8, n = 5), and IL-7Rα KO (Day 0, n = 5; Day 8, n = 5) mice by oral administration of 4% DSS for 4 d. Proportion (IgM/CD3ε) at day 8 (B) and absolute number of IgM⁺ cells in the large intestine at day 0 (normal, open bar) and day 8 (recovery, shaded bar; C) are shown. The large intestine from IL-7Rα KO mice at day 8 was subjected to immunohistochemical analysis for detection of IgM⁺ cells (D). Presence of statistical significance (P < 0.001) compared with day 8 WT mice is indicated by **. Bars, 100 μm.