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. Author manuscript; available in PMC: 2009 Feb 1.
Published in final edited form as: Cytokine Growth Factor Rev. 2008 Feb;19(1):41–52. doi: 10.1016/j.cytogfr.2007.10.004

Fig. 2.

Fig. 2

Cytokines and dendritic cell activation. DCs both produce cytokines and are susceptible to cytokine-mediated activation. Thus, exposure to DC activators, for example TLR ligands or microbes, triggers secretion of pro-inflammatory cytokines including type I interferons (IFN), acute phase cytokines such as TNF and IL-6, IL-1 as well as IL-12 family (left panel). Several cytokines are able to trigger DCs activation (maturation) either in autocrine or paracrine fashion including IL-1, TNF, type I IFNs and TSLP (right panel).