Fig. 7.

The Scribble (Scrb), Discs large (Dlg) and Lethal giant larvae (Lgl) proteins localize to the basolateral membrane domain in polarized epithelial cells. Scrb and Lgl exist in a complex but it is not clear if the interaction is direct. Inset: During the process of cell–cell contact formation, Lgl forms a transient complex with aPKC and PAR-6 from which PAR-3 is excluded. After aPKC-induced dissociation of Lgl from the complex, PAR-3 associates with PAR-6 and aPKC which promotes TJ formation and the development of apical and basolateral membrane domains. Double arrows with solid lines indicate direct protein–protein interactions, double arrows with broken lines indicate the presence of the two proteins in the same complex but the nature of the interaction has not been characterized in detail, yet