Table 1.

Modulation of TJ barrier function in human disease

Classification	Tight junction protein affected	Reference
Cancer
Breast cancer: invasive ductal cancer	Claudin-1, ZO-1	Itoh and Bissell (2003), detailed here
Prostate cancer: prostatic adenocarcinomas	Claudins-1, -3, -4 and claudin-7	Sheehan et al. (2007)
Thyroid neoplasma, follicular adenoma	Occludin and claudin-1, -4 and -7	Tzelepi et al. (2007)
Gastroesophageal reflux disease: Barrett’s  esophagus (dysplasia)	Claudin-18	Jovov et al. (2007)
Lung cancer: Basaloid squamous carcinoma	Ultrastructural junctional dedifferentiation	Gilcrease and Guzman-Paz (1998)
Inflammation
Inflammatory bowel disease: Morbus Crohn	Claudins-2,-3, -5, and -8, ZO-1	Zeissig et al. (2007), detailed here
Collagenous collitis	Occludin, claudin-2 and -4	Burgel et al. (2002)
Multiple sclerosis	Occludin, claudin-5	Förster et al. (2007), detailed here
Hereditary diseases
Hereditäry deafness	Claudin-14	Ben-Yosef et al. (2003), detailed here
Familial hypomagnesemia	Claudin-16	Simon et al. (1999), detailed here
cystic fibrosis	Occludin, claudin-1, -4, JAM, ZO-1	Coyne et al. (2002)
Vision loss
Diabetic eye disease: diabetic retinopathy	Occludin, ZO-1	Felinski and Antonetti (2005), detailed here
Viral infection
Reoviral infection (hydrocephalus, encephalitis)	JAM-1	Forrest et al. (2003)
Bacterial toxins
Clostridium perfringens enterotoxin	Claudin-3 and -4	McClane (2001), detailed here