Fig. 1.

H & E liver sections (250X), from female SD rats showing protective effect of 20% Noni pretreatment d on acute hepatotoxicity at 6 h post-CCl₄ exposure (0.5 mL/kg CCl₄ in corn oil). The rats in a (control) and b (noni treated) received no CCl₄ exposure, and show no signs of liver-cell damage. With CCl₄ exposure, there are significant hepatotoxicity effects: balloon liver cells and apoptotic necrotic cells adjacent to the central vein (arrow and arrowhead (c)). d In contrast, with Noni pretreatment + CCl₄ exposure, shows no signs of hepatotoxicity. b and d (noni treated) show cell patterns that are more ordered, and show no signs of hepatotoxicity