Table 2.
Comparison of symptoms in responders and nonresponders (mean values)
| Admission | Discharge | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Responder | Nonresponder | Responder | Nonresponder | |||||||||
| Measure | mean | SD | mean | SD | p-values | mean | SD | mean | SD | p-values | ||
| n | 76 | 28 | 76 | 28 | ||||||||
| P1 delusions | 4.8 | 1.8 | 4.0 | 1.4 | 0.0445 | 1.5 | 0.8 | 2.1 | 1.0 | 0.0026 | ||
| P2 conceptual disorganization | 4.3 | 1.4 | 2.9 | 1.2 | < 0.001 | 1.6 | 0.8 | 2.4 | 1.1 | < 0.001 | ||
| P3 hallucinatory behavior | 3.7 | 1.8 | 3.0 | 1.7 | NS | 1.1 | 0.3 | 1.6 | 0.9 | < 0.001 | ||
| P4 excitement | 2.7 | 1.7 | 1.8 | 1.0 | 0. 0186 | 1.1 | 0.5 | 1.4 | 0.8 | NS | ||
| P5 grandiosity | 2.0 | 1.5 | 1.5 | 1.0 | NS | 1.2 | 0.6 | 1.5 | 1.0 | NS | ||
| P6 suspiciousness/persecutions | 4.5 | 1.2 | 3.9 | 1.0 | 0.0223 | 1.9 | 0.8 | 2.6 | 0.9 | < 0.001 | ||
| P7 hostility | 1.9 | 1.4 | 1.5 | 0.7 | NS | 1.0 | 0.3 | 1.2 | 0.4 | NS | ||
| Positive subscale PANSS | 24.0 | 6.6 | 18.6 | 3.4 | < 0.001 | 9.4 | 2.5 | 12.7 | 3.9 | < 0.001 | ||
| N1 blunted affect | 3.5 | 1.6 | 2.6 | 1.1 | 0.005 | 2.3 | 1.0 | 3.2 | 0.8 | < 0.001 | ||
| N2 emotional withdrawal | 4.0 | 1.6 | 3.2 | 0.8 | 0.0223 | 2.4 | 1.0 | 3.3 | 0.6 | < 0.001 | ||
| N3 poor rapport | 4.0 | 1.7 | 2.6 | 0.8 | < 0.001 | 2.1 | 1.0 | 3.2 | 1.0 | < 0.001 | ||
| N4 passive/apathetic social withdrawal | 4.0 | 1.6 | 3.2 | 1.1 | 0.0160 | 2.2 | 1.0 | 3.2 | 0.9 | < 0.001 | ||
| N5 difficulty in abstract thinking | 4.7 | 1.8 | 3.0 | 1.4 | < 0.001 | 2.2 | 1.2 | 2.9 | 1.0 | 0.0059 | ||
| N6 lack of spontaneity and flow ofconversation | 3.8 | 1.8 | 2.7 | 1.1 | 0.0036 | 2.0 | 1.0 | 2.8 | 1.2 | 0.0022 | ||
| N7 stereotyped thinking | 4.1 | 1.5 | 3.3 | 0.9 | 0.0135 | 2.1 | 0.9 | 3.2 | 0.7 | < 0.001 | ||
| Negative Subscale PANSS | 28.1 | 9.1 | 20.6 | 4.8 | < 0.001 | 15.6 | 5.5 | 21.8 | 4.5 | < 0.001 | ||
| G1 somatic concern | 2.8 | 2.0 | 2.1 | 1.0 | NS | 1.5 | 0.9 | 2.0 | 1.0 | 0.0228 | ||
| G2 anxiety | 2.9 | 1.6 | 2.8 | 1.1 | NS | 1.3 | 0.7 | 1.7 | 1.0 | 0.0163 | ||
| G3 guilt feelings | 1.9 | 1.4 | 1.8 | 1.2 | NS | 1.4 | 0.8 | 1.6 | 1.2 | NS | ||
| G4 tension | 2.9 | 1.5 | 2.5 | 1.1 | NS | 1.3 | 0.6 | 1.7 | 0.9 | 0.0068 | ||
| G5 mannerisms and posturing | 2.5 | 1.4 | 1.7 | 1.0 | 0.0112 | 1.5 | 0.9 | 1.9 | 1.0 | NS | ||
| G6 depression | 2.4 | 1.5 | 2.5 | 1.4 | NS | 1.6 | 0.9 | 2.2 | 1.1 | 0.0061 | ||
| G7 motor retardation | 2.6 | 1.6 | 2.8 | 1.1 | NS | 2.0 | 1.0 | 2.7 | 0.9 | < 0.001 | ||
| G8 uncooperativeness | 3.0 | 2.0 | 1.7 | 0.9 | 0.0014 | 1.1 | 0.4 | 1.5 | 0.8 | 0.0052 | ||
| G9 unusual thought content | 3.8 | 1.3 | 2.9 | 1.0 | 0.0019 | 1.7 | 0.8 | 2.2 | 0.8 | 0.0059 | ||
| G10 disorientation | 2.2 | 1.5 | 1.3 | 1.1 | 0.0045 | 1.0 | 0.0 | 1.2 | 0.5 | 0.0050 | ||
| G11 poor attention | 4.5 | 1.2 | 3.4 | 0.7 | < 0.001 | 2.5 | 0.8 | 3.0 | 0.7 | 0.0020 | ||
| G12 lack of judgment and insight | 5.1 | 1.3 | 4.2 | 1.0 | 0.0037 | 3.3 | 1.0 | 3.8 | 0.8 | 0.0078 | ||
| G13 disturbance of volition | 4.0 | 1.2 | 3.2 | 1.1 | 0.0042 | 2.3 | 0.9 | 3.1 | 1.1 | < 0.001 | ||
| G14 poor impulse control | 2.1 | 1.4 | 1.4 | 0.7 | 0.0145 | 1.1 | 0.4 | 1.2 | 0.6 | NS | ||
| G15 preoccupation | 4.1 | 1.4 | 3.0 | 1.0 | < 0.001 | 2.1 | 0.9 | 3.0 | 0.8 | < 0.001 | ||
| G16 active social avoidance | 4.0 | 1.5 | 3.0 | 0.9 | 0.0016 | 2.0 | 0.8 | 2.8 | 0.8 | < 0.001 | ||
| General subscale PANSS | 51.0 | 11 | 40.4 | 7.6 | < 0.001 | 27.8 | 6.6 | 35.9 | 8.2 | < 0.001 | ||
| Total Score PANSS | 103.1 | 22 | 79.7 | 12.6 | < 0.001 | 52.7 | 12 | 70.6 | 14.2 | < 0.001 | ||
NOTE: symptom presence–score minimally 4 for individual items; NS – significant level > 0.1.
Abbreviations: Resp responders; nonresp, nonresponders; PANSS, Positive and Negative Syndrome Scale.