Table 4.
Drugs with generally accepted QTc interval prolongation action, organized by class of drug
| Usage/Class of drug | Drug names |
|---|---|
| Alpha1-blocker | Alfuzosin |
| ADHD | Atomoxetine, methylphenidate |
| Antianginal | Bepridila |
| Antiarrhythmic | Amiodarone, disopyramide, dofetilide, flecainide, ibutilide, procainamide, quinidine, sotalol |
| Sympathomimetic (asthma) | Salmeterol |
| Antibiotic | Azithromycin, clarithromycin, erythromycin, fluconazole, gatifloxacin, grepafloxacin, ketoconazole, levofloxacin, moxifloxacin, sparfloxacin, telithromycin |
| Anticancer | Arsenic trioxide, tamoxifen |
| Anticonvulsant | Felbamate, fosphenytoin |
| Antidepressant | Venlafaxine |
| Antiemetic | Ondansetron |
| Antifungal | Voriconazole |
| Antihistamine | Astemizole,a terfenadinea |
| Antihypertensive | Isradipine, moexipril/hydrochlorothiazide, nicardipine |
| Antiinfective | Pentamidine |
| Antimalarial | Chloroquine, halofantrine |
| Antimania | Lithium |
| Antinausea | Dolasetron, domperidone, droperidol, granisetron |
| Antipsychotic | Chlorpromazine, clozapine, haloperidol, mesoridazine, pimozide, quetiapine, risperidone, thioridazine |
| Antiviral | Amantadine, foscarnet |
| Appetite suppressant | Fenfluramine, phentermine, sibutramine |
| Bronchodilator | Salbuterol, ephedrine, levalbuterol, metaproterenol, terbutaline |
| Catecholamine | Dobutamine, epinephrine, isoproterenol |
| Decongestant | Ephedrine, phenylephrine, phenylpropanolamine, pseudoephedrine |
| Diuretic | Indapamide |
| Dopaminergic (Parkinson’s) | Amantadine |
| Endocrine | Octreotide |
| Gastrointestinal stimulant | Cisapride,a erythromycin |
| Immunosuppressant | Tacrolimus |
| Muscle relaxant | Tizanidine |
| Opiate agonist | Levomethadyl, methadone |
| Sedative | Chloral hydrate, droperidola |
| Uterine relaxant | Ritodrine |
| Vasoconstrictor | Epinephrine, midodrine, norepinephrine, phenylephrine |
| Vasodilator | Vardenafil |
| Other | Cocaine |
A more complete up-to-date list of all such agents is available at www.qtdrugs.org.
a
These medications are no longer available in Canada but may still be available elsewhere.