Figure 5. CoCSC phenotype cells are also enriched following Irinotecan treatment.

A) Upon randomization to normalize treatment groups at 400 mm³ at day 43, once weekly administration of vehicle (green boxes) or 15 mg/kg Irinotecan (red triangles) commenced and tumors were measured twice weekly. Growth curves representing the Mean±SEM are shown. B) Percentage of human ESA⁺CD44⁺CD166⁺ CoCSC phenotype cells in residual tumors is shown. Data reflects n≥4 mice per treatment group.