FIG. 2.
Recovery of lymphocyte subsets after treatment (absolute cell counts per mm3). Flow cytometric analysis of lymphocyte subsets was performed on peripheral blood samples within the indicated time ranges. All data from patients who received 60 mg/Kg cyclophosphamide (Cohorts 2, 3, and 4) was included. No patient is represented more than once in a single time range. Pre: values assayed before the start of chemotherapy. A dashed line represents the lower limit of normal values. B cells (CD20+), and NK cells (CD16+ or CD56+ and CD3−) and CD8+ T cells recovered to pre-ablation levels within a few months. CD4+ cell counts remained low for the duration of the study, resulting in low values for total T cells (CD3+), and a depressed CD4+/CD8+ cell ratio.