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. Author manuscript; available in PMC: 2008 Jun 6.
Published in final edited form as: J Immunother. 2002;25(3):243–251. doi: 10.1097/01.CJI.0000016820.36510.89

TABLE 3.

Treatment received by each patient

Cloned cells administered (×10−9)
Patient Cy* Flu IL-2 Source First cycle Second cycle
1 30 25 TIL 22.4 10.4
2 30 25 PBL 21.5 16.0
3 30 25 PBL 15.0 14.5
4 60 25 TIL 9.3 11.0
5 60 25 TIL 4.1 6.0
6 60 25 PBL 5.5 nd§
7 60 25 72,000 PBL 11.0 11.0
8 60 25 72,000 TIL 6.8 7.3
9 60 25 72,000 PBL 3.2 1.8
10 60 25 720,000 PBL 2.8 5.6||
11 60 25 720,000 TIL 11.3 14.0
12 60 25 720,000 PBL 0.9 nd§
13 60 25 720,000 PBL 4.9 6.7
14 60 25 720,000 PBL 12.6 nd
15 60 25 720,000 PBL 24.2 nd
*

Cytoxan (mg/kg)

Fludarabine (mg/m2)

Interleukin-2 (IU/kg)

§

Not done: Patient 6 and Patient 12 received only one infusion of cells due to rapid disease progression.

||

Patient 10 received a mixture of three CD8+ T-cell clones in the second infusion cycle with a total cell number of 5.6 × 109 cells.

Not done: Patient 14 and Patient 15 received only one infusion of cloned cells, then they were transferred to other treatment protocols.