TABLE 3.
Cloned cells administered (×10−9)
|
||||||
---|---|---|---|---|---|---|
Patient | Cy* | Flu† | IL-2‡ | Source | First cycle | Second cycle |
1 | 30 | 25 | — | TIL | 22.4 | 10.4 |
2 | 30 | 25 | — | PBL | 21.5 | 16.0 |
3 | 30 | 25 | — | PBL | 15.0 | 14.5 |
4 | 60 | 25 | — | TIL | 9.3 | 11.0 |
5 | 60 | 25 | — | TIL | 4.1 | 6.0 |
6 | 60 | 25 | — | PBL | 5.5 | nd§ |
7 | 60 | 25 | 72,000 | PBL | 11.0 | 11.0 |
8 | 60 | 25 | 72,000 | TIL | 6.8 | 7.3 |
9 | 60 | 25 | 72,000 | PBL | 3.2 | 1.8 |
10 | 60 | 25 | 720,000 | PBL | 2.8 | 5.6|| |
11 | 60 | 25 | 720,000 | TIL | 11.3 | 14.0 |
12 | 60 | 25 | 720,000 | PBL | 0.9 | nd§ |
13 | 60 | 25 | 720,000 | PBL | 4.9 | 6.7 |
14 | 60 | 25 | 720,000 | PBL | 12.6 | nd¶ |
15 | 60 | 25 | 720,000 | PBL | 24.2 | nd¶ |
Cytoxan (mg/kg)
Fludarabine (mg/m2)
Interleukin-2 (IU/kg)
Not done: Patient 6 and Patient 12 received only one infusion of cells due to rapid disease progression.
Patient 10 received a mixture of three CD8+ T-cell clones in the second infusion cycle with a total cell number of 5.6 × 109 cells.
Not done: Patient 14 and Patient 15 received only one infusion of cloned cells, then they were transferred to other treatment protocols.