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. 1999 Nov 23;96(24):13766–13770. doi: 10.1073/pnas.96.24.13766

Figure 3.

Figure 3

Effect of antisense oligonucleotides on dome formation and maintenance in LA7 cells. (A1) Domes develop in LA7 cells induced to differentiate with 1.5% DMSO for 36 hr after the addition of the inducer. (A2) Addition of anti-rat8 antisense oligonucleotide causes disappearance of domes in DMSO-induced LA7 cells. (A3) Removal of anti-rat8 antisense oligonucleotide allows for reappearance of domes. (B1) Addition of the epithelial Na+ channel β subunit antisense oligonucleotide causes disappearance of domes in 1.5% DMSO-induced LA7 cells. (B2 and B3) Sense and scrambled oligonucleotides had no effect. (C1) Exposure of LA7 to antisense oligonucleotides to the gene 133 in absence of DMSO causes dome formation. (C2 and C3) The 133 sense and scrambled oligonucleotides had no effect.