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8-pCPT does not alter neuronal excitability or presynaptic transmitter release capabilities. (A) Input-output (I/O) curve slopes were not altered by application of 8-pCPT. Linear regressions were calculated for 8-pCPT–treated (n = 12) and control slices (n = 15). (B) Paired pulse facilitation (PPF) was not altered by application of 8-pCPT. 8-pCPT–treated slices (n = 13) exhibited facilitation similar to controls (n = 16) at interpulse intervals of 50, 100, 150, and 200 msec.
