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. 2008 Jun;15(6):403–411. doi: 10.1101/lm.830008

Figure 3.

Figure 3.

LTP elicited by pairing 1 × 100 Hz stimulation with 8-pCPT requires protein synthesis and ERK, but not transcription or PKA. (A) Emetine, a translation inhibitor, blocked the enhancement of LTP by 8-pCPT. (B) Actinomycin D, a transcription inhibitor, had no significant effect on LTP enhanced by 8-pCPT. (C) U0126, an ERK inhibitor, also blocked the enhancement of LTP by 8-pCPT. (D) KT5720, a PKA inhibitor, had no significant effect on LTP enhanced by 8-pCPT. (E) Summary histogram for these experiments comparing levels of potentiation 120 min after HFS (**P < 0.01, *P < 0.05). All sample traces were taken at time points A and B on graphs. Calibration bars: 5 mV, 2 msec.