TABLE 2.
Average rolling velocities (μm/s) of wild-type, CD44-knockdown, CEA-knockdown, and CEA/CD44-double knockdown LS174T cells (106/ml) perfused over a surface coated with 0.75 μg/ml E-selectin at the physiological shear stress levels of 1.0 or 2.0 dynes/cm2
Data represent the mean ± S.E.
|
Average rolling velocity |
||
|---|---|---|
| 1.0 dyne/cm2 | 2.0 dynes/cm2 | |
| μm/s | ||
| Wild-type LS174T | 5.3 ± 0.3 | 7.2 ± 0.4 |
| CD44-knockdown LS174T | 5.1 ± 0.3 | 6.9 ± 0.5 |
| CEA-knockdown LS174T | 5.2 ± 0.4 | 7.1 ± 0.5 |
| CEA/CD44-knockdown LS174T | 5.2 ± 0.4 | 10 ± 1a,b,c |
Values are p < 0.05 with respect to wild-type LS174T cells.
Values are p < 0.05 with respect to CD44-knockdown LS174T cells.
Values are p < 0.05 with respect to CEA-knockdown LS174T cells.