TbUAP expression is essential for the growth of bloodstream
form T. brucei in culture. A, growth curves for wild
type cells, subcultured every 2 days. B, growth curves for
TbUAP conditional null mutant cells, subcultured every 2 days, grown
under permissive (plus tetracycline) conditions. C, growth curves for
TbUAP conditional null mutant cells grown under nonpermissive (minus
tetracycline) conditions. D, ethidium bromide-stained agarose gel of
reverse transcription-PCR products from RNA extracted from TbUAP
conditional null mutant cells after 0, 2, 6, 12, and 48 h and 10 days without
tetracycline, as indicated. The upper panel shows reverse
transcription-PCR products using TbUAP primers, the middle
panel is a control without reverse transcriptase, and the lower
panel is a control using Dol-P-Man synthetase (DPMS) primers to
show equal RNA input.