TABLE 1.
Comparison of recombinant eukaryotic UAP properties
| Species | Molecular mass | GlcNAc-1-P Km | UTP Km | Specific activity | Alternative substrates | Reference/Source |
|---|---|---|---|---|---|---|
| kDa | μm | μm | μmol·min−1·mg− 1 | |||
| T. brucei (TbUAP) | 60.1 | 39 ± 13 | 26 ± 6 | 26 ± 6 | None | This study |
| G. intestinalis (GiUAP) | 49.6 | 300 ± 120 | 38 ± 17 | 9.2 ± 1.9, 55.4 ± 11.1 | Glc 1-phosphate, GalNAc-1-P | Ref. 38 |
| S. cerevisiae (ScUAP) | 53.5 | 14 | 21 | 17 | Glc 1-phosphate | Ref. 37 |
| H. sapiens (AgX1) | 57.0 | 5.3 | 53 | 69 | GalNAc-1-P | Ref. 36 |
| H. sapiens (AgX2) | 58.8 | 6.0 | 49 | 68 | GalNAc-1-P | Ref. 36 |