TABLE 1.
Summary of hydrogen/deuterium exchange in the LRP1 cytoplasmic domain
| Peptide (N to C termini) | Coverage region | Number of amides | Deuteration in LRP1 | Deuteration in LRP1-P (Tyr(P)4507) | Deuteration in LRP1 Y4507E |
|---|---|---|---|---|---|
| 1249.72 | 4442-4452 | 10 | 7.5 ± 0.1 | 8.4 ± 0.2 | 9.7 ± 0.1 |
| 1377.61 | 4452-4464 | 11 | 7.3 ± 0.1 | 9.0 ± 0.3 | 9.1 ± 0.3 |
| 1491.64 | 4453-4465 | 12 | 7.8 ± 0.2 | 9.7 ± 0.3 | 10.1 ± 0.5 |
| 1151.57 | 4466-4475 | 8 | 4.9 ± 0.2 | 6.5 ± 0.1 | 7.9 ± 0.5 |
| 1800.80 | 4465-4480 | 14 | 8.1 ± NAa | 10.4 ± 0.04 | NA |
| 1691.83 | 4493-4507 | 12 | 8.6 ± 0.1 | NA | NA |
| 1838.89 | 4492-4507 | 12 | 11.3 ± 0.1 | NA | NA |
| 1704.74 | 4511-4526 | 15 | 7.1 ± NA | 9.6 ± 0.1 | 10.6 ± NA |
| 1965.03 | 4527-4544 | 15 | 8.6 ± 0.5 | 12.2 ± 0.1 | 11.0 ± 0.1 |
a
NA, not applicable.