FIGURE 4.

Schematic representation of the Lipid Whisker Model. Cell membranes of senescent or apoptotic cells possess oxPL with a variety of oxidized fatty acyl chains of differing structures protruding into the aqueous compartment. This conformation renders them accessible to interact with scavenger receptors and other pattern recognition receptors on the surface of probing macrophages of the innate immune system. It may also render them more accessible for some phospholipases, promoting membrane remodeling as oxidized fatty acids are cleaved and lysophospholipids reacylated. This figure was reprinted from Ref. 22.