FIGURE 4.

Alleviation of motor deficits in male HD transgenic mice by transgenic BAG1. The rotarod test was performed to examine latency to fall (seconds) of transgenic mice. A and B, no significant difference was observed in rotarod performance between male and female wild-type (A) or BAG1 transgenic (B) mice. C, male N171-82Q (Tg) mice show a significant decrease in latency to fall compared with female N171-82Q mice. D, male and female double transgenic (DbTg) mice performed equally well on the rotarod test. E, comparison of male N171-82Q and DbTg mice revealed that mice overexpressing BAG1 performed significantly better than N171-82Q mice. ^*, p < 0.05. F, no significant difference in rotarod performance was seen between female N171-82Q and DbTg mice. The data are presented as mean ± S.E. from three separate groups of F1 littermates. ^*, p < 0.05; ^**, p < 0.01.