Table 1.

Summary of the average (CV%) pharmacokinetic parameters from post-hoc bayesian estimates following protein i.v. injection in juvenile pigs

Form of protein	n	K (1/h)	K12 (1/h)	K21 (1/h)	Vc (L)	Thalf (h)	Vehicle (unit/mL)
BChE/hSA produced in vitro	2	0.0579 (0.0)	0.0993 (100)	0.103 (99.9)	0.581 (0.0)	32.4 (29.8)	1.83 (0.0)
BChE produced transgenically (>70% tetramer)	4	0.689 (28.4)	0.553 (18.4)	0.592 (0.000845)	0.120 (42.9)	2.74 (12.6)	1.45 (0.0)

CV%: The intersubject variation, reported as a percentage (%) of coefficient of variation;

K: The elimination rate constant from the central compartment;

K12: The rate constant of the protein from the central to the first peripheral compartment;

K21: The rate constant of the protein from the first peripheral to the central compartment;

Vc: The volume of the central compartment following i.v. administration;

Thalf: The apparent terminal elimination half-life;

Vehicle: The response detected by the analytical assay that is considered as background activity in untreated juvenile pig plasma, not related to the administration of the protein, using 720 units = 1 mg purified plasma huBChE and assay conditions as described in. [29].