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Model depicting export across two membranes. Both RND and ABC transporters interact with OMFs and MFPs to form a continuous translocation pathway across both the inner and outer membranes of gram-negative bacteria. This model offers one possible juxtaposition, using the structures of the OMF TolC trimer, the MFP MexA, and the RND AcrB trimer. (Reprinted from reference 199 with permission of the publisher. Copyright 2004 National Academy of Sciences, U.S.A.)
