TABLE 1.
MICs of AR-709 and other agents against pneumococci
| Drug and strain susceptibility typea | MIC (μg/ml)
|
||
|---|---|---|---|
| Range | 50% | 90% | |
| AR-709 | |||
| Penicillin S | ≤0.008-2 | 0.06 | 0.25 |
| Penicillin I | ≤0.008-1 | 0.25 | 0.5 |
| Penicillin R | 0.016-2 | 0.25 | 1 |
| Macrolide S | ≤0.008-1 | 0.12 | 0.5 |
| Macrolide R | ≤0.008-2 | 0.25 | 0.5 |
| Quinolone S | ≤0.008-2 | 0.12 | 0.5 |
| Quinolone R | 0.016-2 | 0.25 | 1 |
| SXT S | ≤0.008-0.5 | 0.06 | 0.12 |
| SXT R | ≤0.008-2 | 0.25 | 0.5 |
| SXT | |||
| Penicillin S | 0.03->8 | 0.25 | 4 |
| Penicillin I | 0.12->8 | 4 | 8 |
| Penicillin R | 0.12->8 | 8 | 8 |
| Macrolide S | 0.03->8 | 0.5 | 8 |
| Macrolide R | 0.12->8 | 4 | 8 |
| Quinolone S | 0.06->8 | 4 | 8 |
| Quinolone R | 0.03->8 | 4 | 8 |
| SXT S | 0.03-0.5 | 0.25 | 0.5 |
| SXT R | 1->8 | 8 | 8 |
| Amoxicillin-clavulanate | |||
| Penicillin S | ≤0.016-0.12 | ≤0.016 | 0.03 |
| Penicillin I | ≤0.016-1 | 0.12 | 1 |
| Penicillin R | 0.25-8 | 2 | 4 |
| Macrolide S | ≤0.016-2 | 0.06 | 1 |
| Macrolide R | ≤0.016-8 | 0.12 | 4 |
| Quinolone S | ≤0.016-8 | 0.12 | 2 |
| Quinolone R | ≤0.016-4 | 0.5 | 2 |
| SXT S | ≤0.016-2 | 0.03 | 0.12 |
| SXT R | ≤0.016-8 | 0.5 | 4 |
| Cefuroxime | |||
| Penicillin S | 0.016-0.5 | 0.03 | 0.12 |
| Penicillin I | 0.03-4 | 0.25 | 4 |
| Penicillin R | 1->64 | 4 | 16 |
| Macrolide S | 0.016-8 | 0.25 | 4 |
| Macrolide R | 0.016->64 | 0.5 | 8 |
| Quinolone S | 0.016->64 | 0.25 | 4 |
| Quinolone R | 0.03-8 | 2 | 8 |
| SXT S | 0.016-16 | 0.03 | 0.5 |
| SXT R | 0.016->64 | 2 | 8 |
| Azithromycin | |||
| Penicillin S | 0.03->64 | 0.12 | >64 |
| Penicillin I | 0.03->64 | 0.12 | >64 |
| Penicillin R | 0.03->64 | 8 | >64 |
| Macrolide S | 0.03-0.25 | 0.12 | 0.12 |
| Macrolide R | 1->64 | >64 | >64 |
| Quinolone S | 0.03->64 | 4 | >64 |
| Quinolone R | 0.03->64 | 0.12 | >64 |
| SXT S | 0.03->64 | 0.12 | >64 |
| SXT R | 0.03->64 | 8 | >64 |
| Ciprofloxacin | |||
| Penicillin S | 0.5->32 | 2 | 16 |
| Penicillin I | 0.5-32 | 1 | 4 |
| Penicillin R | 0.5->32 | 2 | 4 |
| Macrolide S | 0.5->32 | 2 | 16 |
| Macrolide R | 0.5->32 | 1 | 4 |
| Quinolone S | 0.5-32 | 1 | 2 |
| Quinolone R | 4->32 | 32 | >32 |
| SXT S | 0.5->32 | 2 | 8 |
| SXT R | 0.5->32 | 1 | 4 |
| Levofloxacin | |||
| Penicillin S | 0.5-16 | 1 | 8 |
| Penicillin I | 0.5-32 | 1 | 2 |
| Penicillin R | 0.5-16 | 1 | 4 |
| Macrolide S | 0.5-16 | 1 | 8 |
| Macrolide R | 0.5-32 | 1 | 2 |
| Quinolone S | 0.5-2 | 1 | 1 |
| Quinolone R | 4-32 | 16 | 16 |
| SXT S | 0.5-16 | 1 | 2 |
| SXT R | 0.5-32 | 1 | 2 |
| Penicillin G | |||
| Penicillin S | ≤0.008-0.06 | 0.016 | 0.06 |
| Penicillin I | 0.12-1 | 0.25 | 1 |
| Penicillin R | 2-16 | 2 | 4 |
| Macrolide S | 0.016-2 | 0.12 | 2 |
| Macrolide R | ≤0.008-16 | 0.25 | 4 |
| Quinolone S | 0.12-16 | 0.12 | 2 |
| Quinolone R | 0.016-4 | 0.5 | 2 |
| SXT S | ≤0.008-4 | 0.03 | 0.25 |
| SXT R | 0.016-16 | 1 | 4 |
a
S, susceptible; I, intermediate; R, resistant; and SXT, trimethoprim-sulfamethoxazole (1:19).