TABLE 2.

MICs of AR-709 and other agents against group A streptococci

Drug and strain susceptibility typea	MIC (μg/ml)
	MIC range	50%	90%
AR-709
Macrolide S	≤0.008-0.12	0.06	0.06
Macrolide R	≤0.008-0.06	0.016	0.03
Trimethoprim-sulfamethoxazole (1:19)
Macrolide S	0.06-0.5	0.12	0.25
Macrolide R	≤0.008-0.5	0.06	0.25
Amoxicillin-clavulanate
Macrolide S	≤0.016-0.03	≤0.016	≤0.016
Macrolide R	≤0.016-0.03	≤0.016	≤0.016
Cefuroxime
Macrolide S	0.016-0.016	0.016	0.016
Macrolide R	0.016-0.03	0.016	0.03
Azithromycin
Macrolide S	0.06-0.25	0.12	0.25
Macrolide R	4->64	>64	>64
Ciprofloxacin
Macrolide S	0.5-4	0.5	1
Macrolide R	≤0.25-2	0.5	2
Levofloxacin
Macrolide S	0.5-2	0.5	2
Macrolide R	0.25-2	0.5	1

^aS, susceptible; and R, resistant.