FIG. 4.

Histopathological examination of lung specimens from mice sacrificed 3 days after infection with VISA Mu50. Each specimen exhibited typical features of bronchopneumonia, with accumulation of neutrophils inside the bronchial lumen, infiltration of acute inflammatory cells, and exudates in the alveolar spaces (hematoxylin and eosin stain; original magnification, ×50). (a) Control mice. (b) SMP-601-treated mice. (c) Vancomycin (VCM)-treated mice. Note that the severity of inflammatory process is lower in the SMP-601-treated group than in the other groups.