TABLE 3.
Rat survival with compound pretreatmenta
| Compound | Dose (mg)/rat | Survival (no. of mice that survived/total no.) | Time to death (min) | P valueb |
|---|---|---|---|---|
| PBS | NAc | 0/20 | 72-100 | |
| 5b | 1.25 | 3/3 | 0.00056 | |
| 5g | 1.25 | 3/3 | 0.00056 | |
| 14b | 1.25 | 3/3 | 0.00056 | |
| 14c | 1.25 | 3/3 | 0.00056 |
a
Fischer rats were injected i.v. with each compound 30 min prior to administration of LT (10 μg PA plus 10 μg LF), and survival was monitored over 8 h.
b
P values were calculated on the basis of the results for each group relative to those for the PBS-treated controls by the use of Fisher's test (two tailed).
c
NA, not applicable.