TABLE 2.

In vitro activities of pradofloxacin and metronidazole against Porphyromonas and Prevotella spp. isolated from canine periodontal pockets

Bacterial group	No. of isolates	MIC (μg/ml)a for:
		Pradofloxacin			Metronidazole
		Range	50%	90%	Range	50%	90%
Porphyromonas asaccharolytica	39	0.031-0.125	0.062	0.062	≤0.016-0.5	0.031	0.125
Porphyromonas circumdentaria/Porphyromonas endodontalis	126	≤0.016-0.5	0.062	0.25	≤0.016-0.5	0.125	0.25
Porphyromonas gingivalis	24	≤0.016-0.25	0.031	0.125	≤0.016-0.5	0.062	0.25
Porphyromonas levii	49	0.031-0.125	0.062	0.125	≤0.016-0.5	0.062	0.125
Porphyromonas macacae	39	≤0.016-0.25	0.062	0.125	≤0.016-0.5	0.125	0.25
Porphyromonas salivosa	33	0.031-0.25	0.125	0.125	0.031-256	0.25	0.5
Prevotella buccae	2	0.25-1	NC	NC	0.5-2	NC	NC
Prevotella corporis	34	≤0.016-0.5	0.062	0.125	≤0.016-16	0.062	0.25
Prevotella denticola	4	0.062-0.125	0.062	NC	0.062-0.25	0.125	NC
Prevotella disiens	8	0.031-0.25	0.062	NC	≤0.016-1	0.062	NC
Prevotella heparinolytica	77	≤0.016-1	0.062	0.25	≤0.016-128	0.25	0.5
Prevotella intermedia	6	≤0.016-0.125	0.031	NC	≤0.016-0.25	≤0.016	NC
Prevotella loescheii	3	0.062-0.125	NC	NC	0.062-0.5	NC	NC
Prevotella nigrescens	26	0.031-0.5	0.062	0.25	≤0.016-2	0.125	0.5
Prevotella oralis	6	0.062-0.25	0.062	NC	0.031-16	0.25	NC
Prevotella oris	9	0.031-0.062	0.062	NC	0.125-1	0.5	NC
Prevotella oulorum	2	0.031-0.125	NC	NC	0.25-0.5	NC	NC
Prevotella zoogleoformans	1	0.125	NC	NC	0.125	NC	NC
Prevotella spp. (undefined)	142	≤0.016-0.5	0.062	0.25	≤0.016-1	0.25	0.5
All Porphyromonas strains	310	≤0.016-0.5	0.062	0.125	≤0.016-256	0.125	0.25
All Prevotella strains	320	≤0.016-1	0.062	0.25	≤0.016-128	0.25	0.5
All strains	630	≤0.016-1	0.062	0.25	≤0.016-256	0.125	0.5

^aMIC₅₀ calculated for groups with ≥4 isolates and MIC₉₀ for groups with ≥10 isolates. NC, not calculated.