TABLE 2.
Susceptibility of the parental and mutant replicon variants to ACH-806 and control inhibitorsa
| Compound | Susceptibility ± SD (μM) of the Luc/Parent replicon at:
|
Fold change in susceptibility ± SD (μM) of the indicated variant repliconb
|
||||||
|---|---|---|---|---|---|---|---|---|
| Luc/NS3-A39V
|
Luc/NS3-C16S
|
Luc/NS5B-I585T
|
||||||
| EC50 | EC90 | EC50 | EC90 | EC50 | EC90 | EC50 | EC90 | |
| ACH-806 | 0.01 ± 0.01 | 0.08 ± 0.01 | 14.0 | 13.7 | 11.1 ± 1.0 | 11.3 ± 0.9 | 0.7 ± 0.1 | 1.1 ± 0.1 |
| NNI-1 | 1.76 ± 0.56 | 7.50 ± 1.00 | 1.0 | 1.1 | 1.1 ± 0.2 | 1.0 ± 0.1 | 1.3 ± 0.4 | 1.1 ± 0.2 |
| PI-1 | 0.90 ± 0.88 | 4.77 ± 2.10 | 1.3 | 0.7 | 0.8 ± 0.4 | 1.1 ± 0.6 | 0.8 ± 0.4 | 1.0 + 0.0 |
| NI-1 | 0.14 ± 0.06 | 1.25 ± 0.44 | 0.9 | 1.2 | 1.2 ± 0.6 | 0.9 ± 0.2 | 1.4 ± 0.8 | 1.1 ± 0.0 |
a
Data shown are averages ± standard deviations of the results from two independent experiments, except for those for the replicon Luc/NS3-A39V, where only one experiment was conducted.
b
Fold changes at EC50 and EC90 were calculated by comparison with those seen with the Luc/Parent replicon.