TABLE 4.
Susceptibility of other resistant cell lines to ACH-806
| Cell line (resistance mutation) | Fold change in EC50 (μM) for the indicated compounda
|
|||||
|---|---|---|---|---|---|---|
| ACH-806 | VX-950 | BILN 2061 | NM107 | NI-1 | NNI-1 | |
| Parental | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 |
| VX-950R (A156T) | 0.6 | 43.7 | >100 | ND | 0.6 | ND |
| BILN 2061R (D168V) | 1.1 | 2.9 | >100 | ND | 1.4 | 0.8 |
| NM107R (S282T) | 0.5 | 0.3 | 1.1 | 30.7 | 11.5 | 2.9 |
| NI-1R (S282T) | 0.8 | ND | 1.4 | >68.7 | 30.3 | 5.0 |
| NNI-1R (M414T) | 0.9 | 2.3 | 2.8 | ND | 0.6 | >28.4 |
a
The fold change in EC50 values was calculated by comparison with those seen with the parent replicon cell line Huh-9-13. The EC50 values ± standard deviations from two independent experiments against Huh-9-13 cells are 0.04 ± 0.03 μM (ACH-806), 0.61 ± 0.14 μM (VX-950), 1.2 ± 0.61 nM (BILN 2061), 1.16 ± 0.1.22 μM (NM 107), 0.56 ± 0.17 μM (NI-1), and 1.37 ± 0.56 μM (NNI-1). ND, not determined.