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. 2005 Sep;1(3):193–204.

Table 3.

Methodological and patient population considerations in brain imaging studies of schizophrenia

  • Technical parameters

    • - Scanner type and strength (1.5T vs 3T)

    • - Image sequence

    • - Slice thickness

    • - Post-processing techniques

    • - Atlas or reference points for anatomical demarcation

    • - Procedure used to determine measurements (automated vs semiautomated vs receiver operated)

  • Illness parameters

    • - Accuracy of diagnosis

    • - Stage of illness (prodromal, first episode, multiepisode, chronic-refractory)

    • - Comorbidities (eg, substance abuse, medical illness)

    • - Medications (antipsychotic naive or medicated, choice of medication)

  • Patient population parameters

    • - Age

    • - Gender composition

    • - Matching to control subjects

    • - Extent of patient attrition in longitudinal studies