Table 1.
Pretreatment demographic and clinical characteristics of all adults enrolled in the study
| Variable | Bupropion SR | Placebo | Total |
|---|---|---|---|
| N | 35 | 24 | 59 |
| Male/female | 25/10 | 18/6 | 43/16 |
| Age (y) (mean ± SD) | 34.3 ± 14.8 | 34.6 ± 11.2 | 34.4 ± 13.4 |
| GAF (mean ± SD) | 53.3 ± 4.6 | 54.6 ± 3.1 | 53.9 ± 4.1 |
| HAM-D (mean ± SD) | 10.0 ± 4.7 | 10.2 ± 5.2 | 10.1 ± 4.9 |
| HAM-A (mean ± SD) | 12.1 ± 5.2 | 11.5 ± 4.7 | 11.9 ± 5.0 |
| Parent Rating Scale (mean ± SD) | 19.8 ± 5.5 | 19.5 ± 5.0 | 19.6 ± 5.1 |
| Screening WRAADDS (total) (mean ± SD) | 20.3 ± 3.7 | 20.2 ± 3.7 | 20.2 ± 3.7 |
| WRAADDS subscales: percentage of patients with at least moderate impairment | |||
| Attention difficulties | 100 | 100 | 100 |
| Hyperactivity | 91 | 96 | 93 |
| Temper | 77 | 79 | 78 |
| Mood instability | 89 | 96 | 92 |
| Overreactivity | 91 | 88 | 90 |
| Disorganization | 97 | 100 | 98 |
| Impulsivity | 94 | 96 | 95 |
| Weissman Social Adjustment Scale: percentage of patients with at least moderate impairment | |||
| Work | 67 | 60 | 64 |
| Social leisure | 50 | 45 | 48 |
| Extended family | 39 | 20 | 30 |
| Marital | 75 | 47 | 62 |
| Parental | 20 | 14 | 17 |
| Overall functioning | 83 | 74 | 79 |
Abbreviations: GAF, Global Assessment of Functioning Scale; HAM-A, Hamilton Anxiety Scale; HAM-D, Hamilton Depression Scale-17 item; WRAADDS, Wender-Reimherr Adult Attention Deficit Disorder Scale.