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Dose–response of Ect virus infection via the footpad of B6 (■), gzmA−/− (×), gzmB−/− (●), perf−/− (□), perf×gzmB−/− (▵), perf×gzmA×B−/− (○), and gzmA×B−/− (▴) mice. Surviving mice were monitored for 21 days. For detection of the respective mutations, DNA of all individual mice was analyzed by PCR as described (20).
