Table 2.

Virus titers and pathology in livers and spleens of different mouse strains

Strain	Mouse no.	Day p.i.	Liver		Spleen
			Infiltration/necrosis	Virus titer	Congestion/necrosis	Virus titer
B6	1	3	−	<200	−	<200
	2		±	<200	−	<200
	3		−	<200	−	<200
	1	6	−	7  ×  105	−	1.3  ×  105
	2		−	7.5  ×  105	−	1.4  ×  105
	3		±	9  ×  105	−	5.3  ×  104
	1	8	±	2.3  ×  105	−	1  ×  105
	2		++	4  ×  104	±	5  ×  103
	3		+	3  ×  103		−8  ×  103
	1	10	+	<200	+	1  ×  105
	2		+	<200	±	<200
	3		±	<200	+	7  ×  103
gzmA−/−	1	3	−	<200	−	<200
	2		±	<200	−	<200
	3		±	<200	−	<200
	1	6	−	1.6  ×  106	−	5  ×  105
	2		±	1.3  ×  106	++	1.3  ×  106
	3		±	1.1  ×  106	−	1.3  ×  106
	1	8	+++	5  ×  103	+	1  ×  104
	2		++	4.4  ×  104	++	4  ×  103
	3		++	7  ×  103	±	2.2  ×  103
	1	10	±	1  ×  103	−	<200
	2		±	1  ×  104	−	<200
	3		±	4  ×  103	−	<200
gzmB−/−	1	3	−	<200	−	<200
	2		±	<200	−	<200
	3		−	<200	−	<200
	1	6	+	4  ×  106	±	5.9  ×  105
	2		+	4.3  ×  106	±	1.4  ×  106
	3		+	3.6  ×  106	+	7  ×  105
	1	8	++	1.8  ×  106	+++	1.5  ×  106
	2		+++	1  ×  106	++++	2.6  ×  106
	3		+++	1.5  ×  106	+++	1.1  ×  106
	1	10	++	2  ×  105	+++	2  ×  105
	2		+	3.4  ×  104	±	2.8  ×  104
	3		±	6  ×  102	+	6  ×  102
gzmA×B−/−	1	3	−	1  ×  103	−	1.7  ×  103
	2		±	1.2  ×  103	−	2.1  ×  103
	3			*		*
	1	6	+	4  ×  107	+++	1.7  ×  107
	2		++	2.4  ×  107	+++	2.5  ×  107
	3			*		*
	1	8	+++	1.3  ×  108	++++	1.5  ×  107
	2		+++	7  ×  107	++++	6  ×  106
	3		++++	1.2  ×  108	++++	5.5  ×  107
	1	10		*		*
	2			*		*
	3			*		*

Liver: Increase in numbers of foci and/or areas affected by cellular infiltration and/or necrosis. Scoring from ±, very few scattered foci of cellular infiltrates and/or necrosis, to ++++, confluency of necrosis in tissue specimens. Spleen: Increase of congestion of sinuses in red pulp and/or of foci of necrosis of white pulp. Scoring from ±, little congestion/very few scattered foci of necrosis, to ++++, extensive congestion/confluency of necrosis in white pulp. 

*Mouse died.