Figure 2.

Effects of oligos, administered alone or in combination with cisplatin, on the growth of the LS174T xenografts in nude mice. Each point represents the mean ± SE of tumor mass from six mice. Oligo AS and Oligo ASM were administered i.p. or by gavage administration at the daily dose of 10 mg/kg 5 consecutive days per week. The control group received physiological saline only. In the combination therapy, animals were treated with Oligo AS or Oligo ASM in the same protocol as above and cisplatin at an i.p. dose of 3 mg/kg twice per week. Oligo AS has significant antitumor effects after administration alone or in combination with cisplatin (P < 0.05) (A). Similar antitumor effects were found after i.p. or gavage administration of Oligo AS at the same dose (10 mg/kg per day) (B).