Figure 5.

Effects of oligos on the growth of human breast cancer MDA-MB-468 xenografts in C.B-17-scid/scid mice (A) and nude mice (B). Each point represents the mean ± SE of tumor mass from six mice. In both strains of mice, the tumor growth was delayed after treatment with Oligo AS compared with untreated or Oligo ASM-treated mice. Specificity was confirmed from the analysis of tumor tissues for the RIα subunits of PKA, which were down-regulated in Oligo AS-treated tumors compared with Oligo ASM-treated or untreated tumors (Fig. 1B).